Abstract- Lithium has a significant impact in reducing the symptoms of bipolar mania but in long periods of use with therapeutic doses can cause several disorders in various organs

Lithium has a significant impact in reducing the symptoms of bipolar mania but in long periods of use with therapeutic doses can cause several disorders in various organs including the reproductive system. In this study on the sperm concentration and motility has been examined. Nowadays, infertility coming from incapability of male system, particularly from sperm disorder is very common. Some types of sperm disorders may result from the medications used by human. The main aim of this was to investigate the in vitro effects of lithium on human sperm motility. Different concentration of lithium was prepared and human semen samples were exposed to lithium solution and the sperm count and motility was examined using routine laboratory method. The results showed that lithium caused decreased motility of sperms with dose dependent pattern, i.e., the more concentarion of lithium applied, the more decrease in sperm motility occurred. In conclusion, lithium has a potential to impair sperm count and motility, so, this aspect of the drug should be considered in patients using lithium.